Drug development

Oligonucleotide adsorption to artificial surfaces

Drug development / Adsorption / Pharmaceutics / Antisense drug / Oligonucleotide

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AGT181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

Engineering / Technology / Immune response / Biotechnology / Drug development / Intelligent Transport System / Western blotting / Genetic Engineering / Biological Sciences / Cerebrospinal Fluid / Brain / Humans / Glucose / Blood Glucose / Blood brain barrier / Animals / Monoclonal Antibodies / Enzyme / Rhesus Monkey / Time Factors / Macaca Mulatta / Enzyme activity / Insulin Receptor / Monoclonal Antibody / Recombinant Protein / Fusion Protein / Enzyme Linked Immunosorbent Assay / Area Under Curve / Enzyme Replacement Therapy / Intelligent Transport System / Western blotting / Genetic Engineering / Biological Sciences / Cerebrospinal Fluid / Brain / Humans / Glucose / Blood Glucose / Blood brain barrier / Animals / Monoclonal Antibodies / Enzyme / Rhesus Monkey / Time Factors / Macaca Mulatta / Enzyme activity / Insulin Receptor / Monoclonal Antibody / Recombinant Protein / Fusion Protein / Enzyme Linked Immunosorbent Assay / Area Under Curve / Enzyme Replacement Therapy

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CaMKII-regulated NMDA receptor expression

Drug development / Dopamine / Glutamate / Drug Design

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Paclitaxel ameliorates renal fibrosis

Drug development / Drug Design / Paclitaxel / Tubulin

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Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites

Kinetics / Drug development / Biological Chemistry / Leishmania / Cell Division / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting

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Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites

Kinetics / Drug development / Biological Chemistry / Leishmania / Cell Division / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting

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Hepatotoxicity, a global problem with local features: Toward the creation of a Pan-American Hepatotoxicity Network | Hepatotoxicidad, un problema global con especificidades locales: hacia la creación de una Red Hispano Latinoamericana de Hepatotoxicidad

Gastroenterology / Drug development / Spain / Latin America / Humans / Data Collection / Latin American / Registries / Clinical Sciences / Adverse Drug Reaction / Liver Disease / Drug Induced Liver Injury / Neurosciences / Data Collection / Latin American / Registries / Clinical Sciences / Adverse Drug Reaction / Liver Disease / Drug Induced Liver Injury / Neurosciences

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Peptide stability in drug development: A comparison of peptide reactivity in different biological media

Rheumatoid Arthritis / Drug development / Pharmaceutical Chemistry / Humans / Liver / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid

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Peptide stability in drug development: A comparison of peptide reactivity in different biological media

Rheumatoid Arthritis / Drug development / Pharmaceutical Chemistry / Humans / Liver / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid

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Preparation and characterization of spironolactone-loaded nano-emulsions for extemporaneous applications

Scanning Electron Microscopy / Crystallization / Nanoparticles / Drug development / Pharmaceutical Chemistry / Oils / Pharmaceutics / Differential scanning calorimetry / Diuretics / Solubility / Chemical Precipitation / Particle Size / Fats / Surface Active Agents / Water soluble polymers / Solid Dispersion / Microspheres / Spray Drying / Drug Carriers / Excipients / Biological Availability / Polyethylene Glycols / Solvents / Oils / Pharmaceutics / Differential scanning calorimetry / Diuretics / Solubility / Chemical Precipitation / Particle Size / Fats / Surface Active Agents / Water soluble polymers / Solid Dispersion / Microspheres / Spray Drying / Drug Carriers / Excipients / Biological Availability / Polyethylene Glycols / Solvents

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Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Organic Chemistry / Drug development / Cell line / Tuberculosis / Humans / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry

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ABC transporters and drug resistance in parasitic protozoa

Medical Microbiology / Drug development / Leishmania / Phylogeny / Humans / Animals / Drug Resistance / Membrane transport / Spectrum / Trypanosoma / Plasmodium falciparum / Antimicrobial agents / Genome sequence / Protozoan Proteins / Amino Acid Sequence / Membrane Protein / Resistance Genes Mechanism) / Animals / Drug Resistance / Membrane transport / Spectrum / Trypanosoma / Plasmodium falciparum / Antimicrobial agents / Genome sequence / Protozoan Proteins / Amino Acid Sequence / Membrane Protein / Resistance Genes Mechanism)

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Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents

Genetics / Microbiology / Medical Microbiology / Drug development / Protein synthesis / Tuberculosis / Mycobacterium tuberculosis / Escherichia coli / Mycobacterium / Mice / Female / Animals / Plasmids / Enzyme / Antibacterial activity / Anti-Bacterial Agents / Buffers / Protease Inhibitors / Antimicrobial agents / Microbial Sensitivity Tests / Culture Media / Recombinant Protein / Drug Targeting / Mycobacterium bovis / Tuberculosis / Mycobacterium tuberculosis / Escherichia coli / Mycobacterium / Mice / Female / Animals / Plasmids / Enzyme / Antibacterial activity / Anti-Bacterial Agents / Buffers / Protease Inhibitors / Antimicrobial agents / Microbial Sensitivity Tests / Culture Media / Recombinant Protein / Drug Targeting / Mycobacterium bovis

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Statistical Model To Evaluate In Vivo Activities of Antimalarial Drugs in a Plasmodium cynomolgi-Macaque Model for Plasmodium vivax Malaria

Microbiology / Medical Microbiology / Drug development / Prodrugs / Mixed Effects Models / Female / Animals / Drug Resistance / Male / Animal Model / South America / Animal Experimentation / Antimalarials / Rhesus macaques / Antimicrobial agents / Macaca Mulatta / Sub Saharan Africa / Statistical Model / Mechanism of action / Host Range / Plasmodium Vivax / Treatment Effect / Female / Animals / Drug Resistance / Male / Animal Model / South America / Animal Experimentation / Antimalarials / Rhesus macaques / Antimicrobial agents / Macaca Mulatta / Sub Saharan Africa / Statistical Model / Mechanism of action / Host Range / Plasmodium Vivax / Treatment Effect

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Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Organic Chemistry / Drug development / Cell line / Tuberculosis / Humans / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry

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In vivo antimalarial activity of ethanolic leaf extract of Acacia auriculiformis

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